Combination of glutathione trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites
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چکیده
Drug Metabolism and Pharmacokinetics Research Laboratories (S.N., H.T., A.W., Y.M., W.S., D.S., T.I.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan Clinical Data and Biostatistics Department (K.S., K.H.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan R&D Planning Department (O.O.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan
منابع مشابه
Combination of glutathione trapping and time-dependent inhibition assays as a predictive method drugs generating highly reactive metabolites
Drug Metabolism and Pharmacokinetics Research Laboratories (S.N., H.T., A.W., Y.M., W.S., D.S., T.I.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan Clinical Data and Biostatistics Department (K.S., K.H.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan R&D Planning Department (O.O.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromac...
متن کاملCombination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Covalent binding (CB) of reactive metabolites (RMs) is potentially involved in severe adverse drug reactions. Because the CB assay is of low throughput and costly, a qualitative trapping assay using agents such as [(35)S]GSH is often performed in the early stages of drug discovery. However, trapping methods alone cannot replace the CB assay. We hypothesized that the time-dependent inhibition (T...
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تاریخ انتشار 2011